Validation evidence

The final package-backed validation used dynamical pancreas velocity and independent deterministic and dynamical velocity fits on the RegVelo Schwann dataset.

The release gate passed

The preserved-graph package reproduction reported FINAL: READY_TO_FREEZE. Across pancreas and both Schwann velocity models, root CFA was stable between effective horizons 64 and 128 and between anchor quantiles 0.85 and 0.95. The deterministic and dynamical Schwann models showed low mean CFA divergence and strong SOF correlation.

Biological stress tests

The validation intentionally retained difficult dynamics:

  • Beta was the clearest forward and fate-resolved pancreas branch.

  • Alpha showed turning behavior.

  • Delta was frequently retrograde and had non-sink-like late anchors.

  • Epsilon showed mixed or loop-like motion.

  • Schwann Gut remained annotation-coherent but strongly retrograde.

These patterns demonstrate why future identity and signed progression must be reported independently.

Condition-scorer validation

Controlled pseudo-condition experiments were used only as software tests. The final Schwann PairScorer recovered a positive ChC CFA shift with adjusted p=0.00794. The Schwann MultiScorer recovered a ChC omnibus adjusted p=0.0162 and a planned control-to-high contrast p=0.0041. These values validate effect recovery; they are not biological treatment results.

Scalability evidence

The no-chunk benchmark measured the complete cellwise DFFP metric transform at 200 million cells and the complete degree-4 sparse graph solve at 100 million cells on the available host. The 200-million-cell full graph solve was marked SKIPPED_INSUFFICIENT_MEMORY rather than replaced by chunking. The separate high-memory runner is required for a direct 200-million-cell full-solve claim.